Identifying the molecular marker(s) for relapse malaria in the Plasmodium vivax
Implementing Organization
National Institute of Malaria Research Delhi (NIMR), New Delhi 110077
Principal Investigator
Dr. Ram Das
Scientist
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National Institute of Malaria Research Delhi (NIMR), New Delhi 110077
CO-Principal Investigator
Dr. N Mishra
Scientist
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National Institute of Malaria Research Delhi (NIMR), New Delhi, 110077
CO-Principal Investigator
Dr. RC Dhiman
Scientist
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National Institute of Malaria Research Delhi (NIMR), New Delhi 110077
National Institute of Malaria Research Delhi (NIMR), New Delhi, 110077 Dr. AR Anvikar, Scientist
CO-Principal Investigator
Dr. D Savargaonkar
Scientist
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National Institute of Malaria Research Delhi (NIMR), New Delhi 110077
CO-Principal Investigator
Dr. N Valecha
Scientist
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National Institute of Malaria Research Delhi (NIMR), New Delhi 110077
Project Overview
Study provided evidence of differentiating relapse and reinfection in P. vivax by newly designed minisatellite markers. These newly designed minisatellite markers are high polymorphic nature. This technique is simple, rapid, cost effective as compared to PCR-RFLP, sequencing, GeneMaper and heteroduplex systems. Minisatellite markers may also be applicable for allelic determination for field studies in areas having high vivax malaria. Genotyping of P. vivax by minisatellite marker has potential to link the infections in community-based studies on relapse, reinfection and transmission of disease also. The generated genotyping data in this study suggest that minisatellite markers are a potential tool to help, drug trial and evolutionary changes within P. vivax strains.