Comprehensive understanding of cellular response to amyloid toxicity at molecular level
Implementing Organization
Institute of Microbial Technology (IMTECH), Chandigarh
Principal Investigator
Dr. Deepak Kumar Sharma
Scientist
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Institute of Microbial Technology (IMTECH), Chandigarh
Abstract
The project will study the genetic manipulation of S. cerevisiae for construction of yeast model of alpha synuclein toxicity. The study will lead to the identification of cellular proteins adversely affected by accumulation of the cystolic alpha synuclein inclusions and identification of cellular factors on alpha synuclein mediated cytotoxicity.