Determining the role of pancreatic alpha-cell autophagy in intra-cellular glucagon turnover and its modulation as an anti-diabetic therapy

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Implementing Organization

Sanjay Gandhi Post Gradute Institute of Medical Science (SGPGIMS), Lucknow, Uttar Pradesh 226014

Principal Investigator

Dr. Rohit A. Sinha

Assistant Professor

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPIMS), Lucknow

CO-Principal Investigator

N.A

About

The incidence of diabetes mellitus (DM) and its associated complications has increased at an alarming rate in India. Recent discoveries have shown that besides insulin, glucagon, also is an important contributor to the disease of diabetes. In diabetes, glucagon secretion is significantly upregulated and limiting its level in diabetics is believed to alleviate hyperglycaemia. In this study we attempt to understand and modulate a cellular degradative process known as autophagy to reduce the amount of glucagon content inside the pancreatic alpha- cells which secrete them. We believe that the results obtained from this study would benefit future diabetes research and treatment.

Patents

N.A

Achievements

N.A

Outcome / Output

New knowledge generation and translational implication to go for Phase-I clinical trials

Publications

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Funding Organization

The Wellcome Trust/DBT India Alliance

Quick Information

Area of Research

Life Sciences & Biotechnology

Focus Area

Diabetic therapy

Start Year

2017

End Year

2022

Sanction Amount

₹ 3.39 Cr

Status

Completed

Contact

anthony.rohit@gmail.com

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

N.A

No. of Patents

Filed : 00

Grant : 00

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