Research Projects

The incidence of diabetes mellitus (DM) and its associated complications has increased at an alarming rate in India. Recent discoveries have shown that besides insulin, glucagon, also is an important contributor to the disease of diabetes. In diabetes, glucagon secretion is significantly upregulated and limiting its level in diabetics is believed to alleviate hyperglycaemia. In this study we attempt to understand and modulate a cellular degradative process known as autophagy to reduce the amount of glucagon content inside the pancreatic alpha- cells which secrete them. We believe that the results obtained from this study would benefit future diabetes research and treatment.