Mutagenesis of M. tuberculosis glyceraldehyde-3-phosphate dehydrogenase (M.tb GAPDH) to identify key residues involved in protein multifunctionality
Implementing Organization
National Institute Of Pharmaceutical Education And Research (NIPER), Mohali
Principal Investigator
Dr. Chaaya Iyengar
Assistant Professor
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National Institute Of Pharmaceutical Education And Research (NIPER), Mohali
Project Overview
To create selected mutations in the sequence of M.tb GAPDH (Rv 1436), to express and purify individual mutant proteins, and to evaluate the effect of these mutant ions on the multifunctional properties of GAPDH (i.e Transferrin binding /Plasminogen binding)