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Identification of COVID-19 associated extracellular vesicles as a prognostic tool and an alternative to SARS-CoV-2 infection and transmission

Implementing Organization

Institute of Liver and Biliary Sciences
Principal Investigator
Dr Sukriti Sukriti
Assistant Professor
|
Institute of Liver and Biliary Sciences

About

This study hypothesises that EVs may serve as reservoirs of SARS–CoV-2, transmit COVID-19 infection to naïve cells and the EV associated SARS–CoV-2 RNA may also contribute in reactivation after the viral clearance.

Patents

NA

Achievements

NA

Outcome / Output

This study found in all confirmed positive COVID-19 patients that the nasal swabs also had extracellular vesicles (EV) associated viral RNA. Whereas it was undetected in the plasma in the same patients but it was positive in 1 per cent of patients with EV associated SARS–CoV-2 RNA. Interestingly, the EV associated were of endothelial cells as detected using flow cytometry.

Publications

NA

Related Research

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Funding Organization
Funding Organization
Department of Science and Technology (DST)
Quick Information
Focus Area
COVID-19 Prognostics
Start Year
2020
End Year
2020
Sanction Amount
₹ NA
Status
Completed
Contact
sukritibiochem@gmail.com
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
NA
No. of Patents
Filed : 00
Grant : 00
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