Emetine was found to be a low nanomolar (nM) inhibitor against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) besides exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus). Emetine treatment led to a decrease in viral RNA and protein synthesis. In a chromatin immunoprecipitation (CHIP) assay, emetine was shown to disrupt the binding of SARS-CoV-2 mRNA with eIF4E, a cellular cap-binding protein required for initiation of protein translation.
Scientist
National Research Centre on Equines (NRCE), Haryana
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