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Therapeutic gene targeting by CRISPR-Cas system: advancement of editing platforms and proof-of-concept disease correction in patient derived cells

Implementing Organization

CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), Delhi
Principal Investigator
Dr Debojyoti Chakraborty
Scientist
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Institute of Genomics and Intergrative Biology (IGIB), University Campus, New Delhi

About

Objective: Creation of highly precise genome editing agents for therapeutic genome editing and their preclinical applications in disease models. Systematic elucidation of nucleic acid interrogation properties of genome editing proteins for improving gene correction. Peptide based delivery of CRISPR components. Establish a disease-specific and gene corrected isogenic control iPSC repository for monogenic diseases that afflict Indian population. Identification of New CRISPR-Cas Components from Microbial Genomes and Metagenomes of Various Niches from India.

Funding Organization
Funding Organization
Council of Scientific and Industrial Research
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Gene editing
Start Year
2020
End Year
2025
Status
Completed
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
N/A
Startup (If Any)
00
No. of Patents
Filed :00
Grant :00
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