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In vivo RNAi mediated intervention in neuro-inflammation pathway for development of therapeutic strategy

Implementing Organization

CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi
Principal Investigator
Beena Pillai
Scientist
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CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi

About

Objective: To study the effect of (1a) miR-29 mimic (1b) miRNA against anti-interferon gamma mRNA and (1c) anti-VDAC1 peptide (developed by international collaborator) in reducing the expression of interferon gamma induced genes in cell lines and in vivo mouse brain. To generate an (2a)AAV9-TBP system (2b) AAV9-HTT system with embedded intrans containing shRNA against the endogenous gene. Evaluate the efficacy of agents developed in (1) and (2) on HTT mice to revert neurodegeneration and ataxia.

Related Research

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Funding Organization
Funding Organization
Council of Scientific and Industrial Research
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Neuro-inflammation pathway
Start Year
2020
End Year
2023
Status
Completed
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
N/A
Startup (If Any)
00
No. of Patents
Filed :00
Grant :00
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