Research Projects

Objective: 1. Mechanistic evaluation of HAUSP inhibitors and their affectivity in GB cells when used alone or in combination with MDM2 inhibitor. 2. Reactivation of both p53 and Rb circuits by restoration of their stability from MDM2 mediated degradation in vitro and in vivo in GBM. 3. Development of PLGA and liposome based novel nanoformluation for cost effective targeted delivery of drugs and reducing off target effect. 4. Cryo-EM based structural determination of HAUSP-Mdm2-p53-Rb complex. 5. To study the interaction mode of HAUSP-Mdm2-p53-Rb complex in order to develop interface interaction based inhibitory peptide to conquer glioma development.