Molecular regulators associated with the maintenance of human trabecular meshwork stem cells in relation to their reduction in ageing and glaucoma
Implementing Organization
Aravind Medical Research Foundation
Principal Investigator
Dr GowriPriya Chidambaranathan
Scientist
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Aravind Medical Research Foundation
CO-Principal Investigator
Dr Muthukkaruppan Veerappan
Professor
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Aravind Medical Research Foundation
CO-Principal Investigator
Dr Krishnadas SubbaiahRamaswamy
Scientist
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Aravind Medical Research Foundation
CO-Principal Investigator
Dr Bharanidharan Devarajan
Scientist
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Aravind Medical Research Foundation
Project Overview
Glaucoma is a leading cause of blindness worldwide with Primary Open Angle Glaucoma (POAG) as the predominant form. It has been suggested that the age and disease-related decrease of Trabecular Meshwork (TM) cells, abnormal accumulation of ECM materials, and the appearance of the cross-linked actin networks in the TM cells contribute to an increased resistance of the AH outflow and subsequent increase of Intraocular Pressure (IOP). Recently confirmed the presence of stem cells in native TM cells by two parameter analysis–high expression of ABCG2 with high N/C ratio.
Aravind Medical Research Foundation
Scientist
Acces sibility Controls