To investigate the catalytic and non-catalytic roles of replicative DNA polymerases in preserving replication fork integrity during replication stress
Implementing Organization
Islamic University of Science & Technology
Principal Investigator
Dr Rais Ahmad Ganai
Assistant Professor
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Islamic University of Science & Technology
CO-Principal Investigator
Dr Mushtaq Ahmad Siddiqi
Assistant Professor
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Islamic University of Science & Technology
About
The study intends to understand the role of the leading strand Polymerase, Pol epsilon in maintaining the replication fork integrity separate from its role in the synthesis of the leading strand. Pol2, the catalytic subunit of DNA Pol epsilon is the focus of this project. Investigators will identify proteins that assist Pol epsilon during normal and stressful settings to preserve the integrity of the genome. This work will help elucidate the mechanistic pathways by which Pol epsilon, other associated factors and checkpoint machinery act & interact to fine-tune the stability of the replication fork stability.
Islamic University of Science & Technology
Assistant Professor
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