miRNA loaded nanoparticles: Investigation and validation of targeted miRNA delivery as A prospective antiviral approach against HSV-2 infection
Implementing Organization
National Aids Research Institute (ICMR-NARI), Maharashtra
Principal Investigator
Dr Anupam Mukherjee
Scientist
|
National Aids Research Institute (ICMR-NARI), Maharashtra
CO-Principal Investigator
Dr Abdul Arif Khan
Scientist
|
National Aids Research Institute (ICMR-NARI), Maharashtra
About
Almost 500 million people belonging to the 15-49 years age group were living with HSV-2 infection, worldwide. HSV-2 infection is sexually transmitted and leads to genital ulcers and increased risk of acquisition of HIV with higher transmissibility to partners and neonates. This study will not only elucidate the direct role of the inflammasome in HSV-2 infection but also investigate the inflammasome-induced pyroptosis pathway, shedding light on the checkpoints that can be modulated to extenuate HSV-2 pathogenesis in the host.