Understanding the mechanism of degradation of cytoplasmic DNA containing alkyl-adducts
Implementing Organization
Indian Institute of Technology(IIT), Hydrabad
Principal Investigator
Dr. Anindya Roy
Professor
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Indian Institute of Technology(IIT), Hydrabad
CO-Principal Investigator
Dr. Sandipan Ray
Indian Institute of Technology(IIT), Hydrabad
About
The study aims to investigate the molecular mechanism of cytoplasmic DNA degradation by TREX1, a nuclease involved in normal cell DNA regulation. The research suggests that cytosolic DNA might be endogenously alkylated and resist TREX1-mediated degradation, leading to the accumulation of alkylated DNA in the cytosol. The project will use high-resolution mass-spectrometry to examine endogenous alkylation in cytoplasmic DNA, synthetic oligonucleotides containing specific DNA alkyl-adducts, and in vitro assays to determine the effect of DNA containing abasic sites or methyl-adducts on CGAS activity.
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Indian Institute of Technology(IIT), Hydrabad
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