Novel paradigms for the development of antioxidant-based radio-protective agent by targeting Nrf2 for ameliorating radiation-induced damages
Implementing Organization
Principal Investigator
Dr. Tamizhselvan Gnanasekaran
Assistant Professor
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K. S. Hegde Medical Academy, Mangalore
CO-Principal Investigator
Dr. Gollapalli Pavan
NITTE University
NITTE University, Karnataka Dr. Suchetha Kumari N
About
The study found that ferulic acid (FA) can reduce radiation-induced DNA damage in peripheral blood. FA was treated with Keap1-Nrf2 protein-protein interaction, a cellular drug target, and showed a significant reduction in reactive oxygen species and DNA damage. The study suggests that FA could be a potential radio-protective agent, with in silico approaches for screening as a better antioxidant-based radio-protector. Quantitative data is needed to understand biological processes in vitro/in vivo.
Assistant Professor
K. S. Hegde Medical Academy, Mangalore
NITTE University, Karnataka Dr. Suchetha Kumari N
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