The role of interleukin (IL)-35 in dendritic cell suppression during Leishmania donovani infection
Implementing Organization
Institute of Microbial Technology (IMTECH)
Principal Investigator
Dr. Pradip Sen
Senior Principal Scientist
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Institute of Microbial Technology (IMTECH)
CO-Principal Investigator
Dr. S Kumaran
Institute of Microbial Technology (IMTECH)
About
Visceral leishmaniasis, caused by Leishmania donovani, is the second most deadly parasitic disease globally. Its pathogenic factor is profound immunosuppression, which is largely unknown. Dendritic cells (DCs) play a crucial role in initiating antileishmanial immune responses. The study aims to investigate if LD induces IL-35 expression in DCs, how LD mediates this effect, and if DC-derived IL-35 has any role in suppressing DCs, T cells, and antileishmanial immunity. This research will help understand the innate immune mechanism by which LD induces immunosuppression to promote the disease.
Institute of Microbial Technology (IMTECH)
Senior Principal Scientist
Acces sibility Controls