Combating the Undruggable Ternary EGFR L858R-T790M-C797S Mutation Associated with Osimertinib for the Treatment of Non-Small Cell Lung Cancer (NSCLC)
Implementing Organization
Principal Investigator
Dr. Harun M. Patel
Associate Professor
|
R.C. Patel College of Pharmacy, Shirpur
About
The US FDA approved Osimertinib (AZD9291) for treating metastatic EGFR-T790M NSCLC. However, a significant number of patients developed a C797S mutation, rendering Osimertinib resistant. This suggests a need for drugs to overcome this resistance obstacle. The current proposal focuses on designing and synthesizing fourth-generation triple mutant selective EGFR-L858R-T790M-C797S tyrosine kinase inhibitors to overcome this resistance in NSCLC chemotherapy.
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Associate Professor
R.C. Patel College of Pharmacy, Shirpur
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