Research Projects

The mammalian system relies on over 200 proteins, including the Fe/S cluster, for enzyme catalysis, electron transfer reactions, and metabolic pathways. The mitochondrial matrix's core machinery, including proteins like ISCU, ISD11, NFS1, Frataxin, and ACP, is essential for the biosynthesis of Fe/S clusters. Genetic defects can lead to severe mitochondrial-specific pathological conditions, such as ISCU-specific mitochondrial myopathy in humans. The study aims to understand the impact of these mutations on Fe/S cluster biosynthesis and iron homeostasis to better manage disease progression. The study will also explore the significance of the N-terminal region of ISCU and NFS1, a protein essential in Fe/S cluster biogenesis. The results will help improve disease management and treatment.