Elucidating the Interplay between Ligand-Binding and DNA-Recognition in the Transcription Regulator CytR
Implementing Organization
Indian Institute of Technology (IIT), Madras
Principal Investigator
Dr. Athi Narayanan Naganathan
Associate Professor
|
Indian Institute of Technology, Madras
About
CytR, a transcription regulator, plays a crucial role in E. coli's energy metabolism, particularly under stressed conditions. It regulates gene expression, maltose utilization, and heat-shock response. CytR's multi-functionality is due to its interaction with multiple promoter regions, including the uniquely disordered DNA binding domain (DBD). However, little is known about CytR's structural-mechanistic features, such as the cytidine binding signal and its binding affinity. The binding affinity is significant between two sub-domains of the LBD, suggesting a pre-equilibrium between open and closed conformations. Mutations can be engineered into CytR LBD to alter binding affinity.
Science and Engineering Research Board (SERB), New Delhi
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Biotechnology, Genetic Engineering
Start Year
2023
End Year
2025
Sanction Amount
₹ 49.07 L
Status
Completed
Contact
athi@iitm.ac.in
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
00
No. of Patents
Filed :00
Grant :00
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Indian Institute of Technology (IIT), Madras
Associate Professor
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