Unravelling the molecular mechanisms of Spinocerebellar Ataxia 8 non-coding RNA pathogenesis associated neurodegeneration using Drosophila model
Implementing Organization
Banaras Hindu University
Principal Investigator
Dr. Mousumi Mutsuddi
Associate Professor
|
Banaras Hindu University
CO-Principal Investigator
Prof. Ashim Mukherjee
Banaras Hindu University
About
The study uses a Drosophila model of Spinocerebellar Ataxia 8 to understand the molecular genetics of the disorder. RNA binding proteins (RBPs) like muscleblind, split ends, staufen, and spoonbill are identified as potential modulators. Spoonbill RBP, with a KH RNA binding domain, suppresses SCA8-associated neurodegeneration and motor problems. The researchers plan to explore the mechanisms of SCA8 pathogenesis and their implications for other disorders like myotonic dystrophy using Drosophila models.
Science and Engineering Research Board (SERB), New Delhi
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Molecula Biology, Genetics
Start Year
2023
End Year
2025
Status
Completed
Contact
mousumi@bhu.ac.in
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
00
No. of Patents
Filed :00
Grant :00
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Banaras Hindu University
Associate Professor
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