Isolation, characterization and pharmacological evaluation of seaweed poly-/oligosaccharides in inorganic arsenic exposure-induced cognitive impairments by targeting gut-microflora-brain axis

Implementing Organization

Principal Investigator

Dr. Dhirendra Pratap Singh

Scientist C

Icmr- National Institute Of Occupational Health, Gujarat

CO-Principal Investigator

Dr. Ramavatar Meena

CSIR-Central Salt & Marine Chemicals Research Institute (CSIR-CSMCRI), Gujarat

CO-Principal Investigator

Dr. Kamalesh Prasad

CSIR-Central Salt & Marine Chemicals Research Institute (CSIR-CSMCRI), Gujarat

CO-Principal Investigator

Dr. Pramod Bapurao Shinde

CSIR-Central Salt & Marine Chemicals Research Institute (CSIR-CSMCRI), Gujarat

CO-Principal Investigator

Dr. Santasabuj Das

National Institute of Cholera and Enteric Diseases, West Bengal;

Project Overview

Arsenic, a common environmental toxins, has been linked to neurotoxic effects on the gut microbiota. Seaweed polysaccharides, which are FDA-approved food ingredients, have potential for use in cognition management. Researchers aim to extract and chemically characterize these polysaccharides from seaweeds and prepare their oligomers. The extracts will be evaluated in a validated rodent model against inorganic arsenic exposure-induced cognitive impairments. The study also aims to identify new therapeutic options for treating SYNGAP1-related Intellectual Disability (ID) and Autism Spectrum Disorder (ASD) in children. A small molecule activator, TTK21, has been found to induce long-term memory and assist in the complete recovery of memory in Alzheimer's mice.

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Quick Information

Area of Research

Cognitive Sciences and Psychology

Focus Area

Neurotoxicology, Biological Science

Start Year

2023

Sanction Amount

₹ 39.36 L

Status

Ongoing

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

N/A

Startup (If Any)

No. of Patents

Filed :00

Grant :00

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