Surface Engineering of Biomedical Implants for the Prevention of MDR Infection
Implementing Organization
Principal Investigator
Dr. Selvakumar Murugesan
National Institute Of Technology, Mangalore, Karnataka, 575025
Project Overview
Bacterial infections in biomedical implants cause severe damage and lead to implant failure, surgery, and re-implantation. Current antibiotics are ineffective due to their limited ability to reach damaged tissue, MDR development by bacteria, and toxic side effects. A new project aims to develop a novel coating formulation using natural polyphenol tannic acid, engineered spider silk protein, and 2D-nanomaterial MXenes for synergistic triple-mode antibacterial action. The formulation will be extended to scaffolds and studied for biofilm formation and antimicrobial characteristics using various assays. This will lead to a universal low-cost coating technology for various medical substrates.