Research Projects

Synthesis of highly functionalized and optically active carbocycles is an attractive target in synthetic organic chemistry due to their prevalence in several natural products, bioactive compounds and materials. In this regard, copper catalyzed stereoselective transformations on wide range of ?-systems has become one of the most powerful tool. Moreover, this method allows the difuctionalization of electron-rich ?- systems such as alkenes and alkynes with various electrophiles which tremendously increases the diversity. Compare to most of the transition-metals, copper is an inexpensive, low toxic and highly abundant metal. In particular, asymmetric hydrocupration or borocupration of various functional groups followed by the trapping with diverse electrophiles has a significant interest in academic and industry research. In 2000, Hosomi and Miyaura research groups first reported copper-catalyzed conjugate borylation. Later, Yun and Hoveyda groups developed enantioselective borylation of active alkenes. Similarly, Stryker and co-workers reported the 1,4-reduction of ?,?-unsaturated olefins with ligated CuH hexamers. Later, many research groups published Cu-H promoted transformations. Recently, research efforts focused on the exploring of asymmetric hydrocupration or borocupration followed by an intermolecular and intramolecular trapping of transient organocopper intermediate with electrophiles to access unique carbocycles and heterocycles with multiple stereocenters. This proposal demonstrate the copper(I)-catalyzed asymmetric reductive and borylative transformations on various electron-rich ?-systems and subsequent trapping of transient organo-copper complex with diverse range of electrophiles