Research Projects

The development of new bioactive molecules for anti-cancer treatment is a challenging task due to their nonspecific distribution and poor pharmacokinetic profiles. The first therapeutic peptide, insulin, has been reported and several peptide drugs have been used worldwide. Photodynamic therapy (PDT) is another approach that generates cytotoxic reactive oxygen species (ROs) to target specific diseases. This project aims to develop advanced, better-targeting peptide conjugated metal complexes, which are biocompatible and effective for target-specific disease control using combinational therapy. The peptide amphiphile with metal complex is advantageous due to their high affinity, easy modification, low toxicity, low cost, bioavailability, and metabolic instability. synthesis and development of appropriate drug molecules are crucial for effective treatment of multiple diseases, and this project aims to achieve synthetic methodologies for designing biocompatible peptide-based metal complexes through structural modification of systems induced by intracellular enzymes, photolysis, or bioactive molecules. This will enable the active form of the molecule for applications in photo-sensitizer, chemo-sensing, and target-specific therapeutic activity.