Research Projects

Nonsteroidal anti-inflammatory drugs (NsAIDs) have shown promise as anticancer agents, with their combination with chemotherapeutic drugs resulting in cancer prevention, chemosensitization, and reduced toxicities. However, prolonged use can lead to kidney failure and increased cardio-toxicity. Preclinical studies show that novel celecoxib-based analogues have significant efficacy and reduced toxicity in cancer cells. selenium and organoselenium molecules act as both anti-oxidants and pro-oxidants, depending on the cellular redox environment. synthesis of selenated derivatives of anti-inflammatory scaffolds could yield chemo-protective and chemo-sensitizing agents. Metabolically stable sel-heterocycles can be incorporated on NsAID scaffolds to leverage their therapeutic benefits.