Aptamer based electrosensor for detection of NDMA impurity (a potential carcinogen)
Implementing Organization
Birla Institute of Technology
Principal Investigator
Dr. Abhimanyu Dev
Birla Institute of Technology
CO-Principal Investigator
Dr. Monika Dwivedi
Birla Institute of Technology
CO-Principal Investigator
Dr. Vimal Kumarsing Yadav
Birla Institute of Technology
About
The proposal aims to develop a rapid and cost-effective method for detecting NDMA impurity in active pharmaceutical ingredients (APIs) and drug products. Nitrosamines are carcinogenic impurities found in many drug products, posing a serious threat to human health. The proposed method uses an aptamer-based electrosensor, which can detect NDMA impurity rapidly, eliminating the need for complex analytical methods. The electrosensor will be developed using capture sELEX technique, involving target-induced selection, enrichment, and isolation of DNA aptamers. The expected outcome is the development of an aptamer-based electrosensor for NDMA detection in APIs and pharmaceutical drug products.
Source
Source
science and Engineering Research Board (sERB), DsT
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