Research Projects

Obesity-induced adipose tissue maladaptive response is primarily due to inflammation and fibrosis. Elevated F2RL3 protein in obese individuals could be a potential target to alleviate fibrosis and inflammation in adipose tissue. F2RL3 is activated by key effector proteases of coagulation and inflammatory pathways. In obesity, there is a hypercoagulable state with increased levels of prothrombotic molecules and a pro-inflammatory state with immune effectors activating F2RL3. The study aims to compare F2RL3 expression and influencers between obese and non-obese individuals, observe changes in inflammasome and fibrosis genes, and investigate if BMs-986120 can block the action of proteases from activating the F2RL3 receptor. This study will provide new insights into F2RL3 activation in obese individuals and its role in insulin resistance progression.