Identification and Functional Characterization of TGF-beta1-mediated Activating Transcription Factor-3 sumoylation in Breast cancer Bone Metastasis
Implementing Organization
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu
Principal Investigator
Dr. selvamurugan Nagarajan
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu
CO-Principal Investigator
Dr. Koustav sarkar
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu
CO-Principal Investigator
Dr. Margaret salomi G
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu
Project Overview
Transforming growth factor-beta1 (TGF-beta1) is a crucial cytokine in maintaining cell homeostasis and suppressing tumor progression. However, breast cancer progresses when this anti-proliferative response is lost. TGF-beta1's disturbance in cancer is attributed to a small group of immediate TGF-beta1 target genes. TGF-beta1 strongly stimulates and maintains the level of activating transcription factor-3 (ATF-3) in human breast cancer cells and mouse mammary pad tumor cells. ATF-3 is also highly expressed in human primary tumor tumors, with Cyclin A1, MMP-13, and Runx2 being ATF-3 target genes. This proposal aims to identify and functionally characterize TGF-beta1-stimulated ATF-3 sumoylation and its sites using in vitro and in vivo models. The findings could lead to translational research for developing small molecules against ATF-3 sumoylation in controlling breast cancer progression and bone metastasis.
SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu
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