Research Projects

Antimicrobial resistance (AMR) is a global threat causing 7,000 deaths annually and is expected to grow to 10 million by 2050. The World Health Organization has included several gram-positive and gram-negative bacteria in the high Priority Pathogen list. The discovery pipeline for new antibiotics has dried up, and resistance development against most antibiotics is urgent. A new broad-spectrum antibiotic compound, A32C2, has been isolated from Paenibacillus dendritiformis and has shown promising results against EsKAPE infections. The objective is to elucidate the mechanism of action, evaluate the spectrum of antibiotics, and develop efficient formulations for future use. The findings will lead to proof of concept for pre-clinical and clinical studies.