Mechanism of chiral proofreading of DTD2 from archaea and plants

Acces sibility Controls

Implementing Organization

CSIR- Centre For Cellular And Molecular Biology (CSIR–CCMB), Hyderabad, Telangana

Principal Investigator

Dr. Rajan Sankaranarayanan

CSIR- Centre For Cellular And Molecular Biology (CSIR–CCMB), Hyderabad, Telangana

About

Land plants have developed metabolic pathways that involve the production of reactive aldehydes and their detoxification to survive harsh environments. A chiral proofreader, DTD2, plays a critical role in detoxifying anaerobic stress-induced acetaldehyde modification of D-aminoacyl-tRNA. This study aims to identify DTD2's role in protecting plants from metabolically generated aldehydes, elucidating its mechanism of chiral selectivity and adduct activity, and identifying key residues involved in its biochemical activities. Understanding molecular determinants providing aldehyde modification specificity in DTD2 can help engineer DTD2 protein for a broader range of protection from various cellular metabolites.

Source

Anusandhan National Research Foundation/Science and Engineering Research Board (SERB), DST 2023-24

Related Research

View All

Funding Organization

Science and Engineering Research Board (SERB), New Delhi

Anusandhan National Research Foundation (ANRF)

Quick Information

Area of Research

Life Sciences & Biotechnology

Focus Area

Biochemistry, Structural Biology

Start Year

2024

End Year

2027

Sanction Amount

₹ 68.21 L

Status

Ongoing

Contact

sankar@ccmb.res.in

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

No. of Patents

Filed : 00

Grant : 00

Acces sibility Controls

Research Projects