Designing Colloidal Nanodrug for Blood-Brain Barrier Crossing
Implementing Organization
Indian Association For The Cultivation Of Science, West Bengal
Principal Investigator
Dr. N R Jana
Department of Condensed Matter Physics and Materials Science, SN Bose Natioanl Centre for Basic Sciences, Kolkata, West Bengal, 700098
Indian Association For The Cultivation Of Science
Project Overview
This project aims to create a 10-100 nm colloidal nanodrug that can cross the blood-brain barrier. The nanodrug will consist of inorganic nanoparticles, polymers, micelles, surfactants, and small molecules, with an affinity molecule. It will have enhanced transcytosis, nanomotor activity, and ultrasound responsive properties. The nanodrug will enhance brain targeting by efficient crossing the blood-brain barrier. The project will involve preparation, performance testing, and in vivo studies for optimal systems. The nanodrug could be used for treating neurodegenerative diseases and brain tumors.