Research Projects

The proposed synthetic strategy can be utilized for the synthesis of complex molecules with highly substituted chiral THF rings in a one pot, step and atom economical process.6 This protocol will give direct access for the synthesis of drugs and intermediates and biologically active natural product analogs which contains enantioenriched THF moiety. The above discussed natural products are synthesized in multistep, low yield and expensive catalyst which will increase the production cost of the chiral drug molecules1,8 therefore, it is essentially required for the development of simple process. Many natural products has chiral THF subunits and the proposed methodology cost effective, environmentally friendly, nontoxic, eco-friendly, scale-up, safe, and efficient to prepare such molecules. The present protocol avoids the usage of toxic metals, therefore, the product should be harm-free to human health. The proposed work will be of interest in organic chemistry, medicinal chemistry as well as many branches of chemistry in application basis. The synthesized compound will be screened for medicinal properties and their other biological activities.10 The results obtained from this project will be submitted, as manuscripts, for publication to internationally-recognized, high-impact, peer-reviewed journals and will be submitted for patent rights. We will be approaching to pharmaceutical industries for which will be interested to invest in innovative protocols for the synthesis of complex molecules after the successful establishment of the present protocol. The Ph. D. students will get trained during the implementation of the project.