Research Projects

Poor ovarian response (POR) is a significant challenge in assisted reproductive technology (ART), resulting in reduced oocyte retrieval after ovarian stimulation (OS). The incidence of POR varies worldwide and contributes significantly to poor pregnancy rates in ART cycles. Understanding the pathophysiological mechanisms leading to POR is crucial for improving ART outcomes. Age is considered an important causative factor, but there is limited knowledge about its aetiology in young patients with normal ovarian reserve markers. Ovarian response is also influenced by single nucleotide polymorphisms (SNP)/genetic variants present in hormone receptors that play a crucial role in normal folliculogenesis. Certain genetic variants in follicle stimulating hormone (FSHR), androgens (AR), estradiol (ESR), and aromatase (CYP19A1) genes have been associated with POR. Additionally, there is a link between POR and altered follicular microenvironment, which determines oocyte and embryo developmental potential. This study proposes understanding the altered follicular microenvironment and granulosa cell function in association with genetic variants found in hormone receptors of FSH, androgens, estradiol, and CYP19A1 in women undergoing ART cycles. The study will include patients categorized using novel POSEIDON criteria to avoid heterogeneity observed in other classification systems of POR. The basic knowledge gained from this project will have significant translational value in the field of ART, helping improve treatment strategies for poor responders and developing individualized ovarian stimulation protocols for patients with POR.