Research Projects

The study aims to develop a one-step methodology for synthesizing the core of biologically active cyclopentane rings fused with heterocycles containing N and O. This approach is enantioselective and remote stereo controlled, with the group already synthesizing starting materials for the methodology in a previous project. The focus will be on coupling reactions (Heck, Negishi, suzuki) on the synthesized iodination product and cyclization of these moieties. The next target is to carry out the asymmetric synthesis of furan and pyran ring fused with cyclopentene-1,3 dione using chiral organo-catalyst and metal-ligand complex with good enantioselectivity and diastereoselectivity in a single step with remote stereo control. The study also plans to perform template-assisted distal C-H functionalization on the meta and para positions of the newly introduced aryl ring in cyclopentene-1,3 diones with various acrylates, alkenes, alkynes, and sulfones.