Research Projects

The research on Dermal Wound Healing has been challenging due to the generation of reactive oxygen species (ROs) at the wound site, leading to oxidative stress, DNA breakage, and protein inactivation. This project aims to develop a rational strategy using chiral orchestration in peptidyl fragments, incorporating omega amino acids at the N-terminus and therapeutic bioactive molecules like Ferulic Acis/Retinoic Acis/Gallic Acid for healthy wound recovery. The chiral tuning process will lead to a tighter fibrillar network, fine-tuning the mechanical integrity and proteolytic stability of hydrogels. Mechanical stress as stimuli will not only allow a desired formulation to be injected into a patient, but also maintain the biocompatibility of the molecules. The hydrogels' amphiphilic nature allows them to penetrate the cellular membrane of microorganisms, resulting in antimicrobial, anti-inflammatory, and anti-oxidant efficacy. The collective efforts of these properties will synergistically deplete Reactive Oxygen species (ROs) at the wound site, accelerating the healing process and forming mature skin structure in acute wounds more efficiently than existing drugs. The fabrication of these intelligent systems could utilize cutting-edge technologies to design bacteriotherapy and address inflammation-related complications. Continued developments in molecular engineering will provide insights into effective wound healing strategies.