Research Projects

The impact of metal ions on human life has led to a growing interest in chemical sensors, particularly in the development of selective chemosensors for metal ions detection. In supramolecular chemistry, the detection and in situ sensing of biologically significant cations are crucial due to their wide range of applications in biological processes and chiral recognition. In 1987, Donald J. Cram, Charles J. Pedersen, and Jean-Marie Lehn received the Nobel Prize in Chemistry for their outstanding contribution to this field. A recent field in supramolecular chemistry is the rational design and synthesis of new fluorescent chemosensors, which have gained scientific maturity. These chemosensors are crucial for detecting cations and can map the concentration or activity of ions, ligands, or macromolecules in living cells over time. The dynamic range and response kinetics of biosensors are essential for multidimensional visualization, as they directly impact the sensor's spatial and temporal resolution. Cations exposure can cause various health issues, including autism spectrum disorders, infant mortality, respiratory diseases, allergies, cardiovascular disorders, endothelial dysfunction, mental disorders, oxidative stress, kidney diseases, cancer, and neurological diseases. Despite numerous studies, finding innovative methods and mechanisms for designing fluorescence probes remains an ongoing interest. The current project aims to design and synthesize multi-analyte biological molecular probes based on thioureas for bioimaging and safe environmental applications. The probes will undergo FTIR, 1H-NMR, 13C-NMR, s-XRD, Ms, UV-Vis, and fluorescence analysis to investigate their properties.