Research Projects

Cardiovascular diseases (CVDs) are a significant global health concern, characterized by the accumulation of reactive oxygen species (ROs) in myocardial tissue, leading to lipid peroxidation, DNA damage, and protein oxidation. Angiotensin-II, a key molecule in the renin-angiotensin-aldosterone system, is linked to ROs production in cardiomyocytes hypertrophy and myocardial remodeling. Despite available pharmacological interventions, no undying treatment is available for myocardial infarction. This study aims to explore therapeutic interventions against CVD, focusing on myocardial infarction. The study will use modern analytical tools like GC-Ms, LC-Ms-QTOF, Preparative HPLC, and NMR to detect active components of medicinal plants. The proposed study will explore the traditionally used medicinal plants of the North-East Region of India, Phlogacanthus thyrsiformis and Phlogacanthus curviflorus, and their active constituents for their cardioprotective activity. Preliminary data indicates that both plants have strong antioxidant properties, and their treatment significantly prevents the isoproterenol-induced decrease in H9c2 cardiomyoblast viability and the generation of reactive oxygen species. The study hypothesizes that these plants might have potential cardioprotective beneficial effects. The objectives of the study include bioactivity-guided fractionation and isolation of bioactive compounds from selected extracts, identification and characterization of bioactive compounds using analytical methods, and pharmacological evaluation of selected bioactive compounds using an in vivo experimental cardioprotective model in rats.