Understanding the mechanism of ICL (Inter crosslink) mediated replication collapse: involvement of Fanconi anemia proteins

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Implementing Organization

National Institute of Technology (Durgapur), West Bengal

Principal Investigator

Dr. sudit s Mukhopadhyay

National Institute of Technology (Durgapur), West Bengal

CO-Principal Investigator

Dr. subhankar RoyBarman

National Institute of Technology (Durgapur), West Bengal

About

Researchers are studying Fanconi anemia (FA), a rare genetic disorder linked to cancer, to understand the mechanisms of genomic instability. FA proteins repair DNA inter-crosslink damage through a unique pathway. Their previous project proposed a novel s-phase checkpoint pathway involving Fanconi anemia protein G. They found that mitomycin C-mediated ICL damage causes the ATR-mediated phosphorylation of serine 7 of FANCG, which is crucial for its interaction with MCM3AP. The researchers hypothesize that acetylation of MCM3 causes the dissociation of MCM3 from the chromatin, leading to the replication halt or s phase checkpoint.

Source

Anusandhan National Research Foundation/science and Engineering Research Board (sERB), DsT 2023-24

Related Research

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Funding Organization

Science and Engineering Research Board (SERB), New Delhi

Anusandhan National Research Foundation (ANRF)

Quick Information

Area of Research

Life Sciences & Biotechnology

Start Year

2023

End Year

2026

Sanction Amount

₹ 50.60 L

Status

Ongoing

Contact

suditmukhopadhy@yahoo.com

Output

No. of Research Paper

Technologies (If Any)

No. of PhD Produced

No. of Patents

Filed : 00

Grant : 00

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Research Projects