Role of pseudouridine modification of the mRNAs of mitochondrial respiratory complex proteins in RNA metabolism and mitochondrial metabolic disorders
Implementing Organization
NIT, Rourkela, Odisha
Principal Investigator
Dr. santosh Kumar
NIT, Rourkela, Odisha
Project Overview
Pseudouridine (ϰ) is a common nucleotide modification found in cellular RNA and mitochondrially encoded mRNAs. It is linked to various diseases such as cancer, MLAsA, MIDD, HIV, X-linked dyskeratosis congenita, and hoyeraal-hreidarsson syndrome. Pseudouridine is found in urine metabolites of cancer patients and saliva of oral squamous cell carcinoma patients. It plays a significant role in cellular activities like translation, RNA stability, and RNA processing. The study aims to identify RBPs binding at the ϰ position and the functions of cells regulated by these interactions. The results will reveal the complex interplay of posttranscriptional RNA modifications with cellular functions and associated human diseases.
NIT, Rourkela, Odisha
Acces sibility Controls