Leveraging Vinyl Azides and in situ Generated Iminium Intermediates for the Synthesis of Cyclic/Acyclic Amines under Redox-Neutral Conditions
Implementing Organization
CSIR-Central Drug Research Institute (CSIR-CDRI), Uttar Pradesh
Principal Investigator
Dr. Nayan Ghosh
CSIR-Central Drug Research Institute (CSIR-CDRI), Uttar Pradesh
Project Overview
The current proposal highlights a unique CC bond forming reaction between vinyl azides and various in situ generated iminium intermediates under transition metal free conditions. Moreover, the proposed reactions may proceed under mild reaction conditions and yield a number of valuable cyclic/acyclic amines under a redox-neutral atmosphere. Notably, the reaction may proceed via direct insertion of metheyleneamino unit into vinyl azides followed by Schmidt-type reaction and 1,5-hydride transfer sequence. In addition, a straightforward and single step strategy to install methyleneamino unit at - position of saturated N-heterocycle is predicted. Furthermore, asymmetric transformation between vinyl azides and aminals to yield enantiopure amines is anticipated.
CSIR-Central Drug Research Institute (CSIR-CDRI), Uttar Pradesh
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