Research Projects

The functionalization of C-H bond provides a powerful synthetic tool in organic chemistry for the transformation of simple substrates to complex molecules. The atom economy and substrate scope are the important practical features. The selective functionalization of distal sp3 C-H bond remains a synthetic challenging goal. The development of effective synthetic method for the site-selective sp3 C-H bond is of great interest that are important in synthetic, medicinal and pharmaceutical sciences. The proposal presents synthetic strategy for the site-selective distal sp3 C-H activation/functionalization using transition-metal-catalysis using directing groups. The distal C-H bond can be functionalized for C-C bond formation of alkyl chains using transition-metal-based catalysis (Pd, Ni, Co, Cu, Fe, etc) with directing groups. These strategies would be utilized for the functionalization of synthetic and biologically important molecules such as norleucine, fenchol, borneol, testosterone, nicotine, nimodipine, etc. The synthetic and mechanistic aspects of the proposed schemes 1-9 will be explored. The biological properties of the potential molecules would be explored with collaboration of BSBE, IIT Guwahati and NIPER, Guwahati.