Research Projects

The proposed project aims to design and synthesize organotin (IV) compounds with functionalized heterocyclic carboxylate ligands. These compounds can be synthesized using azo or Schiff base functionalized ligands, which include functional groups like COOH and OH to increase the coordination site of the ligands. These ligands will be used for the synthesis of organotin (IV) complexes, which could enhance the biological properties of the compounds. The project adopts a new strategy for synthesizing organotin (IV) compounds with functionalized nitrogen base heterocyclic azo-/ Schiff base carboxylate ligands, expecting them to exhibit diverse molecular architectures and potential biological properties. The ligands will be characterized using elemental analyses, IR, and NMR spectroscopy, with assignment achieved using 2D NMR spectra. Tri-organotin precursors will be used for the synthesis of triorganotin compounds, while diorganotin precursors will be used for the synthesis of diorganotin compounds with functionalized azo- and Schiff base carboxylates. The project aims to study the binding nature of pyridine-based heterocyclic, azo-, and Schiff base carboxylate ligands towards different di- and tri organotin (IV) precursors, as well as their biological properties, such as antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer activities. The focus is on the influence of these nitrogen-based heterocyclic functionalized azo- and Schiff base carboxylate ligands on their bonding behavior and biological activities.