Research Projects

Cancer is a major global health issue, with 8.2 million deaths in 2012, with over 60% of new annual cases occurring in Africa, Asia, and Central and South America. In low and middle-income countries, treatment for cancer is often limited, and health systems are often inadequate for cancer detection and treatment. The high cost of treatment, particularly newer cancer medication, exacerbates this issue. The unsustainability of cancer medication pricing is a global issue, creating access challenges in both low- and middle-income countries. Modern lifestyles have disrupted circadian rhythms, which could explain some cancer cases. Understanding the molecular mechanisms linking disruption of circadian rhythm to cancer and how a disrupted peripheral clock contributes to neoplastic transformation is crucial for developing novel circadian clock-based strategies for cancer prevention, control, and therapeutic intervention. The current investigation aims to develop cost-effective Time Controlled Low Density Floating Pulsatile Systems using biodegradable and biocompatible timed release polymers. These polymers are expensive and increase the cost of dosage forms, making cancer treatment expensive for poor patients. The project aims to develop cheaper polymers that reduce dosage costs, making cancer treatment affordable for poor patients. Direct compression is the preferred technology for forming these systems. The timed release polymer plays a crucial role in drug release after a lag period during cancer tumorigenesis and progression.