Research Projects

Transition metal-catalyzed reactions are highly sought after for C-C bond formations due to their ease of transformation. However, challenges remain, such as the need for an appropriate functional handle, multiple coupling sites, and the ability to generate carbo-metal centers only adjacent to the DGs. Synthesis of selectively functionalized multi-cyclic carbo and hetrocycles is highly sought after in synthetic organic chemistry, drug discovery, and biological sciences. One recent focus is the taming of carbometallation of alkynes towards selective synthesis of olefinic compounds. Alkynes have the potential to generate active carbo-metal centers for further modifications, and nucleo-metallation of alkyne offers a more attractive way to generate alkenyl-metal species by evading the prior setup of the electrophile and an extra cyclization event. Carbometallation of alkynes is usually the other important pathway to generate carbo-metal centers in the linear fashion. Trapping of the resultant intermediate is an unmet and lucid area. This project proposes capturing various carbo metal intermediates, including carbenes from intra or intermolecular carbo/heterometallations. The characteristic future of nickel, palladium, and rhodium complexes with respect to stability and carbophilic nature will be thoroughly studied. The resultant libraries of compounds with high diversity will be submitted to our repository for various drug discovery activities. Experience from collaborations in working for CNS/CVS disorders and anti-cancer activities will help us design and synthesize molecules for target-oriented drug discovery.