Research Projects

Functionalization of distal inert C(sp³)-H bonds has shown profound impact in diversification of non-natural molecules. The directing group (DG) , ligands and transition-metal (TM) catalyst plays important for making the process viable that are mostly linked to the mono-functionalization process, Ambiphilic bifunctional transfer reagent (BFT) which contain both electrophilic and nucleophilic source provides a substantial opportunity to enhance molecular complexity in any synthetic realm. Herein, PIs propose a palladium catalyzed ligand enabled mono functionalization as well as unsymmetrical functionalization of inert two γ-C(sp³)-H bonds activation of readily available aliphatic carboxylic acid derivative. In particular, the unsymmetrical functionalization of inert two γ-C(sp³)-H bonds is remain challenging and less explored.