Research Projects

A new concept based on the ligand design and noncovalent catalysis has been proposed for the direct C–H bond borylation of small organic molecules. While several pioneering methods are reported to achieve the borylation of aromatic compounds to prepare important boronic esters using various catalytic conditions, but each type of substrate needs independent catalyst design and DG optimizations in each case, which is an extraordinary challenge. Moreover, in most cases, these reactions were performed by the use of earlier reported ligand systems that often restricted with respect to the reactivity, selectivity, conversion and temperature of the conditions. Thus, considering all these shortcomings, we propose a concept for the direct borylation of small organic molecules integrating two important parameters, such as, ligand design and noncovalent interaction. This ligand design concept is expected to generate new generation of C–H borylation catalysts that would solve many unsolved problems associated with the borylation chemistry. It has also been shown by the initial results that there is no requirement for the employment of bulky directing group for the C–H bond functionalization, the proposed concept would be proficient enough to overcome the current shortcomings. Moreover, the proposed ligand design concept would give a new dimension to the existing core knowledge in the area C–H bond activation and functionalization, especially for the borylation chemistry.