Development of bi-modal transvaginal probe and evaluation of its diagnostic accuracy for a non-invasive AI-based detection of preinvasive cervical lesion in comparison to standard colposcopy in screen positive patients
Implementing Organization
Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) Pondicherry
Principal Investigator
Dr. Arpitha A
Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) Pondicherry
CO-Principal Investigator
Dr. s Murali
Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, Dr. sreekumaran Nair N, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, Dr. Uttam Mrinal Pal, Indian Institute of Information Technology, Design And Manufacturing, Chennai,Tamil Nadu, JIPMER
Project Overview
Cervical cancer is the fourth leading cause of mortality globally, with slow progression taking about ten years. Current techniques, such as cytology and colposcopy, are costly and require skilled workers. A transvaginal probe has been proposed to estimate cancer biomarkers like glycogen, Protoporphyrin IX, HbO2, and Hb, to differentiate cancerous tissues from normal ones. The probe uses autofluorescence and multispectral diffuse reflectance spectroscopy to detect an increase in porphyrin and target isosbestic points for HbO2 and Hb. The probe also quantifies protein, glycogen, and nuclear index on the cervix's peripheral tissue, distinguishing pre-cervical cancer from normal cases.
Source
Source
science and Engineering Research Board (sERB), DsT
Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) Pondicherry
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