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Resolution of Bitot's spots after administration of mega-dose of vitamin A in a cohort of children in 1-5 years of age with Bitot's spot

Implementing Organization

Principal Investigator
Umesh Kapil
All India Institute of Medical Sciences (AIIMS), New Delhi 110029
CO-Principal Investigator
Prof. Umesh Kapil
Professor, All tndia Institute of Medical Sciences Ansari Nagar, New Delhi-110029, Prof. Shraddha Dwivedi, Professor and Head,, Department of Community Medicine MLN Medical College, Allahabad Uttar Pradesh shraddha.dwivedi@gmail.com
CO-Principal Investigator
Prof. H.P.S. Sachdev
Senior Consultant Pediatrics and Clinical Epidemiology Sitaram Bhartia Institute of Science and Research B-16, Qutab Institutional Area, New Delhi-110016, hpssachdev@gmail.com
CO-Principal Investigator
Prof. S.N. Dwivedi
Professor, Department of Biostatistics All tndia Ins

Project Overview

Bitot’s spot is a useful indicator of vitamin A deficiency, especially in young children, but is not pathognomonic. Substantial non-response to MVAS at 6 and 12 months of follow-up suggests that presently in the Indian subcontinent, Bitot’s spot is a relatively crude indicator of severe current vitamin A deficiency. Thus for programmatic decisions and evaluation, public health burden of VAD should not be solely assessed through BS; it would be desirable to consider other important health consequences. The findings may also partially explain: (i) the recorded discrepancy between BS and low serum retinol prevalences at population level in India; and (ii) the fact that the predominant decline in BS prevalence, antedated a functioning universal vitamin A supplementation programme in India . This decline has, however, now stagnated for a considerable period despite an improvement in MVAS coverage suggesting that factors other than severe VAD deficiency may be operating. It would be useful to revisit the guidelines for management of individual children with BS.

Achievements

Trained 01 SRF and 04 field investigators
Funding Organization
Funding Organization
Indian Council of Medical Research (ICMR), New Delhi
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Nutrition
Start Date
2010
End Date
2012
Status
Completed
Contact
umeshkapil@gmail.com;shraddha.dwivedi@gmail.com;hpssachdev@gmail.com;dwivedi@hotmail.com; rmpandey@yahoo.com
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
00
Publications
01
No. of Patents
Filed : 00
Grant : 00
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