Research Projects

The study aims to investigate the potential of HA@PDA@LND/ERT-MSNPs, which are chemotherapeutics, for photothermal therapy in treating brain tumors. The presence of polydopamine (PDA) in these nanoparticles allows for stable nanocomposites and a positive charge on their surface, forming electrostatic interactions with mucin in the nasal cavity. The study will compare intravenous and intranasal routes for HA@PDA@LND/ERT-MSNPs for targeting brain tumors. PDA can increase temperature in the tumor microenvironment, demonstrating photothermal therapy in treating brain tumors. The pH-sensitive polymers used in the synthesis help collapse the nanostructure at the acidic tumor micro-environment, resulting in burst release of LND at the tumor site. The targeting moiety (HA) conjugated on the surface of PDA@LND/ERT-MSNPs exhibits targeting efficiency at the target site and reduces toxicity to healthy cells. MSNPs as a carrier help load the maximum amount of LND and ERT, reducing multiple dosing. Thus, HA@PDA@LND/ERT-MSNPs can be utilized for pH-responsive dual-modal therapy platforms in brain tumor treatment. The study will investigate the effect of surface modifications on the stability of ERT and LND, develop and characterize ERT and LND co-loaded MSNPs, and investigate the efficiency of MSNPs and surface modified MSNPs in treating brain tumors. The study will also investigate the effectiveness of chemotherapy, photothermal, ferroptosis, stimuli-responsive, and targeting efficiency of synthesized MSNPs.