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Therapeutic gene targeting by CRISPR-Cas system: advancement of editing platforms and proof-of-concept disease correction in patient derived cells

Implementing Organization

Principal Investigator
Dr Debojyoti Chakraborty
Scientist, IGIB

Project Overview

Objective: Creation of highly precise genome editing agents for therapeutic genome editing and their preclinical applications in disease models. Systematic elucidation of nucleic acid interrogation properties of genome editing proteins for improving gene correction. Peptide based delivery of CRISPR components. Establish a disease-specific and gene corrected isogenic control iPSC repository for monogenic diseases that afflict Indian population. Identification of New CRISPR-Cas Components from Microbial Genomes and Metagenomes of Various Niches from India.

Funding Organization
Funding Organization
Council of Scientific and Industrial Research (CSIR), Government of India
Quick Information
Area of Research
Life Sciences & Biotechnology
Focus Area
Gene editing
Start Date
2020
End Date
2025
Status
Completed
Contact
souvik@igib. res. In
Output
No. of Research Paper
00
Technologies (If Any)
00
No. of PhD Produced
00
Publications
00
No. of Patents
Filed : 00
Grant : 00
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